E-viri
Recenzirano
Odprti dostop
-
Majka, M; Ho, R D J G; Zagorski, M
Physical review letters, 03/2023, Letnik: 130, Številka: 9Journal Article
We explain the principles of gene expression pattern stabilization in systems of interacting, diffusible morphogens, with dynamically established source regions. Using a reaction-diffusion model with a step-function production term, we identify the phase transition between low-precision indeterminate patterning and the phase in which a traveling, well-defined contact zone between two domains is formed. Our model analytically explains single- and two-gene domain dynamics and provides pattern stability conditions for all possible two-gene regulatory network motifs.
