Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 μA/(mM · cm 2 ) are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).