Alternative sources of neutron production other than nuclear fission reactions are important priorities in medical and nuclear applications due to costs, safety and ease of operation. In this work, Formula omitted and Formula omitted thick targets for neutron production through Formula omitted and Formula omitted, respectively, have been manufactured and characterized by different techniques. In order to evaluate the irradiation effects on these materials, the targets were irradiated with 150 keV proton beam. A complete characterization of these samples was performed using scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, Auger electron spectroscopy, X-ray photoemission spectroscopy and Raman spectroscopy. The results of these studies allowed us to establish that even though the irradiated samples present microstructural and chemical structure changes on its surface, the Formula omitted and Formula omitted thick targets were stable and would maintain their performance after proton irradiation at a fluence of Formula omitted and Formula omitted, respectively.