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JIAN CHEN; FREDRICKSON, Vance; YUCHUAN DING; HUAKUN CHENG; NING WANG; FENG LING; XUNMING JI
Stroke (1970), 2013, 2013-Jan, 2013-01-00, 20130101, Letnik: 44, Številka: 1Journal Article
We investigated the potential benefit of using a local infusion of low-dose and cold human albumin in ischemic rats as compared with systemic delivery. Stroke was induced in rats, and at 2 hours treatment groups received 0°C saline or low-dose albumin at 0°C or 37°C infused into the ischemic area. The local low-dose cold albumin infusion, which achieved the hypothermic temperature (P<0.001), produced the greatest reduction in infarct volume and the best recovery of neurological function. The local low-dose cold albumin infusion into the ischemic area offered a combination of regional brain hypothermia and albumin administration, which enhanced neuroprotection and would be beneficial in the clinical setting.
