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Yildirim, Mahmut Emre; Karadurmuş, Nuri; Ökten, İlker Nihat; Türk, Hacı Mehmet; Urakçı, Zuhat; Arslan, Çağatay; Çelik, Sinemis; Dane, Faysal; Şendur, Mehmet Ali Nahit; Bilir, Cemil; Karabulut, Bülent; Cicin, İrfan; Çubukçu, Erdem; Karaca, Mustafa; Ozcelik, Melike; Artaç, Mehmet; Tanrikulu, Eda; Alacacioglu, Ahmet; Açıkgöz, Özgür; Öven, Başak; Geredeli, Çağlayan; Çil, Timucin; Harputluoğlu, Hakan; Kefeli, Umut; Bozkurt, Oktay; Tural, Deniz; Sakin, Abdullah; Yalçın, Şuayip; Gumus, Mahmut
Journal of oncology pharmacy practice, 04/2024Journal Article
Colorectal cancer is one of the leading causes of mortality both globally and in our country. In Turkey, we conducted a multicenter investigation into the effectiveness of second-line treatments and real-life data for patients with RAS wild-type metastatic colorectal cancer (NCT04757311). In this retrospective analysis, records from 28 centers were collected, and histopathological, molecular, and clinical characteristics were documented. Patients were categorized into groups based on their second-line biological treatments: anti-EGFR (Group A and Group B, panitumumab and cetuximab) and anti-VEGF (Group C, bevacizumab and aflibercept). They were then compared within these groups. A total of 588 patients with documented RAS wild-type status were evaluated. The median OS was 15.7, 14.3 and 14.7 months in Group A, Group B and Group C, respectively ( = 0.764). The median PFS of the patients in second-line setting that received panitumumab, cetuximab and bevacizumab/aflibercept were 7.8, 6.6 and 7.4 months, respectively ( = 0.848). According to the results of our real-life data study, there is no significant difference in efficiency between the combination of biological agent and chemotherapy used in the second-line treatments.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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