Background : : Cellulite is a complex aesthetic problem caused by a complex interplay of dermal-fascial septae, lipodystrophy, and inadequate skin elasticity, but reliable solutions for this condition remain elusive.Objective: To evaluate a novel radiofrequency-based body contouring device cleared by the FDA for the temporary improvement in the appearance of cellulite in the thighs and abdomen (NuEra; Lumenis, Ltd., Yokneam, Israel).Methods : : A prospective cohort trial was designed to first collect subjective patient and provider reported outcome measures of safety, comfort, and efficacy of the NuEra system in treatment of thigh cellulite in 9 participants. Following review of this data, the second portion of the trial was conducted using the NuEra system to treat the abdominal area in the same patients, collecting anthropometric measurements using a 3-dimensional imaging system (Vectra M3; Canfield, Parsippany, NJ, USA). Treatment protocol specified 5 treatments at approximately 1 week intervals with a final treatment after a 6 week delay. Results : were assessed at the time of the treatments and at two month following the last treatment. Likert scales were used to evaluate subjective provider and patient experience and a standardized cellulite assessment scale was used to rate the pre and post treatment photographs.Results : : Patients rated the overall level of comfort at 4.3 and satisfaction as 3.3 on a 5-point scale. Pain scale scores during treatment averaged 1.4 on a 5-point scale. Providers reported very high levels of satisfaction with the ease of the treatment (4.3 on a 5-point scale). Evaluation of standardized photographs showed an average improvement of 0.53 (standard deviation SD=0.53), with the average pre-treatment score of 2.2 (SD=0.62) and post-treatment score of 1.64 (SD=0.68). The average reduction in waist and hip circumference measurements was 0.99 cm (SD=2.68 cm) and 0.71 cm (SD=1.44 cm).Conclusion : : Radiofrequency based body contouring is a safe, effective, and well tolerated treatment for thigh cellulite.