Rice is globally the most important food crop and there is a dire need to feed the ever-increasing population by improving its productivity. It has been realised that diseases are the major impediment towards enhancing the productivity of this crop. Despite the advent of modern effective disease control measures such as use of chemicals, bioagents and resistant varieties; agronomic practices still play a vital role in disease management in rice. Optimum use of different agro-techniques can be exploited for efficient control of various devastating diseases like rice blast, sheath blight, bakanae and many more by providing a favourable environment to better crop survival. Besides, appropriate selection of a variety, use of quality seed, method of establishment, planting time, nutrient, water and weed management practices can be well exploited to control various diseases. This manuscript entails to review the work pertaining to use of agronomic practices for exploiting the potential of crop environment interaction through reduced disease infection and to bridge the yield gap for ensuring sustained food security.