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Dolan, Michael-John; Frechter, Shahar; Bates, Alexander Shakeel; Dan, Chuntao; Huoviala, Paavo; Roberts, Ruairí Jv; Schlegel, Philipp; Dhawan, Serene; Tabano, Remy; Dionne, Heather; Christoforou, Christina; Close, Kari; Sutcliffe, Ben; Giuliani, Bianca; Li, Feng; Costa, Marta; Ihrke, Gudrun; Meissner, Geoffrey Wilson; Bock, Davi D; Aso, Yoshinori; Rubin, Gerald M; Jefferis, Gregory Sxe
eLife, 05/2019, Letnik: 8Journal Article
Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In , one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic tools for this region. We generate a collection of split-GAL4 driver lines providing genetic access to 82 LH cell types. We use these to create an anatomical and neurotransmitter map of the LH and link this to EM connectomics data. We find ~30% of LH projections converge with outputs from the mushroom body, site of olfactory learning and memory. Using optogenetic activation, we identify LH cell types that drive changes in valence behavior or specific locomotor programs. In summary, we have generated a resource for manipulating and mapping LH neurons, providing new insights into the circuit basis of innate and learned olfactory behavior.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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