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Munné, Santiago; Cohen, Jacques; Simpson, Joe L; Wilton, Leeanda J; Handyside, Alan H; Thornhill, Alan R; Mastenbroek, Sebastiaan; van der Veen, Fulco; Repping, Sjoerd
The New England journal of medicine, 10/2007, Letnik: 357, Številka: 17Journal Article
To the Editor: Mastenbroek et al. (July 5 issue) 1 report a detrimental effect of preimplantation genetic screening, performed in women of advanced maternal age, on rates of ongoing pregnancy and live birth. We believe this outcome is explained by problems with the authors' methods, both for biopsy and for diagnosis. As Mastenbroek and colleagues note, pregnancy rates after in vitro fertilization (IVF) steadily decline with increasing maternal age, while rates of pregnancy loss concurrently increase. These observations are attributed mostly to chromosome abnormalities in embryos obtained after follicular stimulation (which range from 50% among young patients to nearly 80% among . . .
