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Gu, Lusheng; Li, Yuanyuan; Zhang, Shuwen; Xue, Yanhong; Li, Weixing; Li, Dong; Xu, Tao; Ji, Wei
Nature methods, 11/2019, Letnik: 16, Številka: 11Journal Article
We introduce an interferometric single-molecule localization method for super-resolution fluorescence microscopy. Fluorescence molecules are located by the intensities of multiple excitation patterns of an interference fringe, providing around a twofold improvement in the localization precision compared with the conventional imaging with the same photon budget. We demonstrate this technique by resolving nanostructures down to 5 nm in size over a large 25 × 25 μm field of view.
