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Gibson, Frank S; Singh, Ambarish K; Soumeillant, Maxime C; Manchand, Percy S; Humora, Michael; Kronenthal, David R
Organic process research & development, 11/2002, Letnik: 6, Številka: 6Journal Article
A practical synthesis of l-valyl-pyrrolidine-(2R)-boronic acid (1) is detailed. A previously disclosed synthesis of 1 (Snow, R.; Kelly, T. R.; Adams, J.; Coutts, S.; Perry, C. (Boehringer Ingelheim Pharmaceuticals, Inc.). WO 93/10127, 1993) was significantly improved by developing an efficient process for recycling the costly chiral auxiliary (+)- pinanediol.
