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Pettit, George R; Cichacz, Zbigniew; Barkoczy, Josef; Dorsaz, Ann-Christine; Herald, Delbert L; Williams, Michael D; Doubek, Dennis L; Schmidt, Jean M; Tackett, Larry P; Brune, Daniel C; Cerny, Ronald L; Hooper, John N. A; Bakus, Gerald J
Journal of natural products (Washington, D.C.) 56, Številka: 2Journal Article
A new cell growth inhibitory (P-388 murine leukemia ED50 7.5 micrograms/ml) cycloheptapeptide designated phakellistatin 1 was isolated from two Indo-Pacific sponges, Phakellia costata and Stylotella aurantium. Structural elucidation was accomplished utilizing high field nmr, amino acid analyses, and mass spectral techniques (fab, tandem ms/ms), followed by chiral gas chromatographic procedures for absolute configuration assignments (all S-amino acid units). By these methods phakellistatin 1 1 was found to be cyclo (Pro-Ile-Pro-Ile-Phe-Pro-Tyr), and this assignment was finally confirmed by an X-ray crystal structure determination.
