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Özçubukçu, Salih; Ozkal, Erhan; Jimeno, Ciril; Pericàs, Miquel A
Organic letters, 10/2009, Letnik: 11, Številka: 20Journal Article
A new tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol ligand 3 has been prepared by a triple Cu(I)-catalyzed alkyne−azide 1,3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable complex with CuCl, which catalyzes the Huisgen 1,3-dipolar cycloaddition on water or under neat conditions. Low catalyst loadings, short reaction times at room temperature, and compatibility with free amino groups make 3·CuCl an outstanding catalyst for CuAAC.
