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Alza, Esther; Cambeiro, Xacobe C; Jimeno, Ciril; Pericàs, Miquel A
Organic letters, 09/2007, Letnik: 9, Številka: 19Journal Article
The development of a highly efficient, polymer-supported organocatalyst for the Michael addition of ketones to nitroolefins is described. A 1,2,3-triazole ring, constructed through a click 1,3-cycloaddition, plays the double role of grafting the chiral pyrrolidine monomer onto the polystyrene backbone and of providing a structural element, complementary to pyrrolidine, key to high catalytic activity and enantioselectivity. Optimal operation in water and full recyclability make the triazole linker attractive for the immobilization of organocatalysts.
