E-viri
Recenzirano
-
Koviach, Jennifer L; Chappell, Mark D; Halcomb, Randall L
Journal of organic chemistry, 04/2001, Letnik: 66, Številka: 7Journal Article
To probe the conformational requirements of O-linked glycoproteins for binding to various enzymes and receptors, two conformationally constrained glycosylated amino acids, 2 and 3, were designed. The analogues were found to represent two potential low energy conformations of the parent conjugate, 1, by molecular modeling. A convergent synthesis of both 2 and 3 from d-galactose and l-methionine is presented.
