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Sakmann, Bernhard F.A.S; Spindler, Anthony J; Bryant, Simon M; Linz, Klaus W; Noble, Denis
Circulation research, 2000-November-10, Letnik: 87, Številka: 10Journal Article
A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes by whole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium, midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P <0.05) smaller IpNa than subendocardial and subepicardial myocytes. There was no significant difference in IpNa current density between subepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion of action potential duration across the ventricular wall.
