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Konopleva, Marina; Martinelli, Giovanni; Daver, Naval; Papayannidis, Cristina; Wei, Andrew; Higgins, Brian; Ott, Marion; Mascarenhas, John; Andreeff, Michael
Leukemia, 11/2020, Letnik: 34, Številka: 11Journal Article
Targeting the interaction between tumor suppressor p53 and the E3 ligase MDM2 represents an attractive treatment approach for cancers with wild-type or functional TP53. Indeed, several small molecules have been developed and evaluated in various malignancies. We provide an overview of MDM2 inhibitors under preclinical and clinical investigation, with a focus on molecules with ongoing clinical trials, as indicated by (
