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Connor, Ashton A; Adelman, Max W; Mobley, Constance M; Moaddab, Mozhgon; Erhardt, Alexandra J; Hsu, David E; Brombosz, Elizabeth W; Sanghvi, Mansi; Cheah, Yee Lee; Simon, Caroline J; Hobeika, Mark J; Saharia, Ashish S; Victor, 3rd, David W; Kodali, Sudha; Basra, Tamneet; Graviss, Edward A; Nguyen, Duc T; Elsaiey, Ahmed; Moore, Linda W; Nigo, Masayuki; Drews, Ashley L; Grimes, Kevin A; Arias, Cesar A; Li, Xian C; Gaber, A Osama; Ghobrial, R Mark
Transplantation direct, 04/2024, Letnik: 10, Številka: 4Journal Article
The COVID-19 pandemic has led to an increase in SARS-CoV-2-test positive potential organ donors. The benefits of life-saving liver transplantation (LT) must be balanced against the potential risk of donor-derived viral transmission. Although emerging evidence suggests that the use of COVID-19-positive donor organs may be safe, granular series thoroughly evaluating safety are still needed. Results of 29 consecutive LTs from COVID-19-positive donors at a single center are presented here. A retrospective cohort study of LT recipients between April 2020 and December 2022 was conducted. Differences between recipients of COVID-19-positive (n = 29 total; 25 index, 4 redo) and COVID-19-negative (n = 472 total; 454 index, 18 redo) deceased donor liver grafts were compared. COVID-19-positive donors were significantly younger ( = 0.04) and had lower kidney donor profile indices ( = 0.04) than COVID-19-negative donors. Recipients of COVID-19-positive donor grafts were older ( = 0.04) but otherwise similar to recipients of negative donors. Donor SARS-CoV-2 infection status was not associated with a overall survival of recipients (hazard ratio, 1.11; 95% confidence interval, 0.24-5.04; = 0.89). There were 3 deaths among recipients of liver grafts from COVID-19-positive donors. No death seemed virally mediated because there was no qualitative association with peri-LT antispike antibody titers, post-LT prophylaxis, or SARS-CoV-2 variants. The utilization of liver grafts from COVID-19-positive donors was not associated with a decreased overall survival of recipients. There was no suggestion of viral transmission from donor to recipient. The results from this large single-center study suggest that COVID-19-positive donors may be used safely to expand the deceased donor pool.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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