During the time period of 1 March 2001–1 April 2008, the Composition and Distribution Function (CODIF) Analyzer on board Cluster observed 41 prolonged He+ energization events, lasting for 1.10–4.97 h, on average, 3.18 ± 0.91 h. These He+ heating events occurred predominantly at low/middle magnetic latitudes (MLAT = −4.3°–51.7°) in the afternoon sector (MLT = 11:32–19:06) in the outer magnetosphere (L = 7.9–14.6). During the events, the He+ ions resonantly interacted with electromagnetic ion cyclotron (EMIC) waves and were perpendicularly energized to energies up to 1 keV. Their contribution to total ion density in the energy range of 0.04–1 keV was elevated on average up to 51%. A superposed epoch analysis of the plasma data measured by Cluster during these events indicates the presence of the two EMIC wave‐controlling factors: hot anisotropic H+ (the wave free‐energy provider) and cold dense plasma (the wave generation catalyst). In addition, it is common in the events that the density of the energetic H+ is elevated and electron plasma/gyrofrequency ratio (fpe/fce) reaches values higher than 10. Quiet solar wind and geomagnetic activity appear to be favorable conditions for the generation of the EMIC waves and thus the resultant He+ energization in the outer‐magnetospheric region. The reason is that, under quiet solar wind and geomagnetic conditions, an overlap of hot anisotropic H+ from the plasma sheet and cold dense plasma from a plasmaspheric plume or plume‐like region could exist in the afternoon sector of the outer magnetosphere. Key Points Cluster observed 41 prolonged He+ energization events in the outer magnetosphere Hot anisotropic H+ and cold dense plasma were present during the events Quiet geomagnetic activity is favorable for the generation of the events