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Petr, Michael A; Alfaras, Irene; Krawcyzk, Melissa; Bair, Woei-Nan; Mitchell, Sarah J; Morrell, Christopher H; Studenski, Stephanie A; Price, Nathan L; Fishbein, Kenneth W; Spencer, Richard G; Scheibye-Knudsen, Morten; Lakatta, Edward G; Ferrucci, Luigi; Aon, Miguel A; Bernier, Michel; de Cabo, Rafael
eLife, 04/2021, Letnik: 10Journal Article
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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