E-viri
Recenzirano
-
Grahek, Rok; Milivojevič, Dušan; Bastarda, Andrej; Kračun, Matjaž
Journal of Chromatography A, 05/2001, Letnik: 918, Številka: 2Journal Article
The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. The mobile phases consisted of water or mixtures of water–methanol and water–acetonitrile. Six different displacers were successfully used. Up to 0.14 g of raw sample per gram of stationary phase was loaded on a column packed with silica-based octadecyl phase. Crude substances from 85 to 88% chromatographic purity were purified and at least 99.5% purity was achieved.
