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Dai, Yu; Lim, Jin Xuan; Yeo, Samuel Chao Ming; Xiang, Xiaoqiang; Tan, Kai Soo; Fu, Jia Hui; Huang, Lizhen; Lin, Hai‐Shu
Molecular nutrition & food research, January 2020, 2020-01-00, Letnik: 64, Številka: 2Journal Article
Mol. Nutr. Food Res. 2020, 64, 1900905 DOI: 10.1002/mnfr.201900905 In article number 1900905, Hai‐Shu Lin and co‐workers find that piceatannol is extensively converted to two pharmacologically active metabolites, rhapontigenin and isorhapontigenin, by catechol‐O‐methyltransferase. Moreover, piceatannol is identified as a substrate inhibitor of catechol‐O‐methyltransferase. This study also suggests that active metabolites and reversed metabolism of piceatannol contribute to its health‐promoting effects.
