E-viri
Recenzirano
Odprti dostop
-
Dumitrescu, Logan; Barnes, Lisa L; Thambisetty, Madhav; Beecham, Gary; Kunkle, Brian; Bush, William S; Gifford, Katherine A; Chibnik, Lori B; Mukherjee, Shubhabrata; De Jager, Philip L; Kukull, Walter; Crane, Paul K; Resnick, Susan M; Keene, C Dirk; Montine, Thomas J; Schellenberg, Gerard D; Deming, Yuetiva; Chao, Michael J; Huentelman, Matt; Martin, Eden R; Hamilton-Nelson, Kara; Shaw, Leslie M; Trojanowski, John Q; Peskind, Elaine R; Cruchaga, Carlos; Pericak-Vance, Margaret A; Goate, Alison M; Cox, Nancy J; Haines, Jonathan L; Zetterberg, Henrik; Blennow, Kaj; Larson, Eric B; Johnson, Sterling C; Albert, Marilyn; Bennett, David A; Schneider, Julie A; Jefferson, Angela L; Hohman, Timothy J
Brain (London, England : 1878), 09/2019, Letnik: 142, Številka: 9Journal Article
Autopsy measures of Alzheimer's disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However, despite evidence of sex differences in Alzheimer's disease risk, sex-stratified models have not been incorporated into previous GWAS analyses. We looked for sex-specific genetic associations with Alzheimer's disease endophenotypes from six brain bank data repositories. The pooled dataset included 2701 males and 3275 females, the majority of whom were diagnosed with Alzheimer's disease at autopsy (70%). Sex-stratified GWAS were performed within each dataset and then meta-analysed. Loci that reached genome-wide significance (P < 5 × 10-8) in stratified models were further assessed for sex interactions. Additional analyses were performed in independent datasets leveraging cognitive, neuroimaging and CSF endophenotypes, along with age-at-onset data. Outside of the APOE region, one locus on chromosome 7 (rs34331204) showed a sex-specific association with neurofibrillary tangles among males (P = 2.5 × 10-8) but not females (P = 0.85, sex-interaction P = 2.9 × 10-4). In follow-up analyses, rs34331204 was also associated with hippocampal volume, executive function, and age-at-onset only among males. These results implicate a novel locus that confers male-specific protection from tau pathology and highlight the value of assessing genetic associations in a sex-specific manner.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.