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Pettit, George R; Knight, John C; Collins, Jeremiah C; Herald, Delbert L; Pettit, Robin K; Boyd, Michael R; Young, Victor G
Journal of natural products (Washington, D.C.), 06/2000, Letnik: 63, Številka: 6Journal Article
Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10-5 to 10-7 % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) 1H and 13C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 2 and the newly isolated cribrostatins 3−5 displayed antibacterial and/or antifungal activities.
