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Schreiber, Andreas; Stühn, Lara G.; Huber, Matthias C.; Geissinger, Süreyya E.; Rao, Ashit; Schiller, Stefan M.
Small (Weinheim an der Bergstrasse, Germany), 07/2019, Letnik: 15, Številka: 30Journal Article
The molecular structuring of complex architectures and the enclosure of space are essential requirements for technical and living systems. Self‐assembly of supramolecular structures with desired shape, size, and stability remains challenging since it requires precise regulation of physicochemical and conformational properties of the components. Here a general platform for controlled self‐assembly of tailored amphiphilic elastin‐like proteins into desired supramolecular protein assemblies ranging from spherical coacervates over molecularly defined twisted fibers to stable unilamellar vesicles is introduced. The described assembly protocols efficiently yield protein membrane–based compartments (PMBC) with adjustable size, stability, and net surface charge. PMBCs demonstrate membrane fusion and phase separation behavior and are able to encapsulate structurally and chemically diverse cargo molecules ranging from small molecules to naturally folded proteins. The ability to engineer tailored supramolecular architectures with defined fusion behavior, tunable properties, and encapsulated cargo paves the road for novel drug delivery systems, the design of artificial cells, and confined catalytic nanofactories. A platform of environmentally controlled architectures ranging from twisted fibers to stable vesicles is demonstrated. Supramolecular architectures are designed via a library of amphiphilic elastin‐like proteins (ELPs). Tailored ELPs, responsive to environmental parameters enable the assembly of complex materials with tunable properties. The described assembly protocols yield Protein Membrane‐Based Compartments enabling the encapsulation of delicate cargo.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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