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Russell, Ian J; Mellado Lagarde, Marcia M; Drexl, Markus; Lukashkina, Victoria A; Lukashkin, Andrei N
Nature neuroscience, 07/2008, Letnik: 11, Številka: 7Journal Article
Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaΔENT/ΔENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaΔENT/ΔENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.
