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Mak, Tak W; Tafuri, Anna; Shahinian, Arda; Yoshinaga, Steve K; Wakeham, Andrew; Boucher, Louis-Martin; Pintilie, Melania; Duncan, Gordon; Gajewska, Beata U; Gronski, Matthew; Eriksson, Urs; Odermatt, Bernhard; Ho, Alexandra; Bouchard, Denis; Whorisky, John S; Jordana, Manel; Ohashi, Pamela S; Pawson, Tony; Bladt, Friedhelm
Nature immunology, 08/2003, Letnik: 4, Številka: 8Journal Article
Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl(-/-) and Icos(-/-) mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl(-/-) mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.
