E-viri
Recenzirano
Odprti dostop
-
Wahl, Simone; Drong, Alexander; Lehne, Benjamin; Loh, Marie; Kunze, Sonja; Tsai, Pei-Chien; Ried, Janina S; Zhang, Weihua; Yang, Youwen; Tan, Sili; Fiorito, Giovanni; Franke, Lude; Guarrera, Simonetta; Kasela, Silva; Kriebel, Jennifer; Richmond, Rebecca C; Adamo, Marco; Afzal, Uzma; Ala-Korpela, Mika; Albetti, Benedetta; Ammerpohl, Ole; Apperley, Jane F; Beekman, Marian; Bertazzi, Pier Alberto; Black, S Lucas; Blancher, Christine; Bonder, Marc-Jan; Brosch, Mario; Carstensen-Kirberg, Maren; de Craen, Anton J M; de Lusignan, Simon; Dehghan, Abbas; Elkalaawy, Mohamed; Fischer, Krista; Franco, Oscar H; Gaunt, Tom R; Hampe, Jochen; Hashemi, Majid; Isaacs, Aaron; Jenkinson, Andrew; Jha, Sujeet; Kato, Norihiro; Krogh, Vittorio; Laffan, Michael; Meisinger, Christa; Meitinger, Thomas; Mok, Zuan Yu; Motta, Valeria; Ng, Hong Kiat; Nikolakopoulou, Zacharoula; Nteliopoulos, Georgios; Panico, Salvatore; Pervjakova, Natalia; Rathmann, Wolfgang; Roden, Michael; Rota, Federica; Rozario, Michelle Ann; Sandling, Johanna K; Schafmayer, Clemens; Schramm, Katharina; Siebert, Reiner; Slagboom, P Eline; Soininen, Pasi; Stolk, Lisette; Strauch, Konstantin; Tai, E-Shyong; Tarantini, Letizia; Thorand, Barbara; Tigchelaar, Ettje F; Tumino, Rosario; Uitterlinden, Andre G; van Duijn, Cornelia; van Meurs, Joyce B J; Yang, Tsun-Po; Yuan, Wei; Zhernakova, Alexandra; Batterham, Rachel L; Smith, George Davey; Deloukas, Panos; Heijmans, Bastiaan T; Hofman, Albert; Lindgren, Cecilia M; Milani, Lili; van der Harst, Pim; Peters, Annette; Illig, Thomas; Relton, Caroline L; Järvelin, Marjo-Riitta; Bollati, Valentina; Soong, Richie; Spector, Tim D; Scott, James; McCarthy, Mark I; Elliott, Paul; Bell, Jordana T; Matullo, Giuseppe; Gieger, Christian; Kooner, Jaspal S; Grallert, Harald; Chambers, John C
Nature (London), 01/2017, Letnik: 541, Številka: 7635Journal Article
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype. Here we use epigenome-wide association to show that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 × 10 , range P = 9.2 × 10 to 6.0 × 10 ; n = 10,261 samples). Genetic association analyses demonstrate that the alterations in DNA methylation are predominantly the consequence of adiposity, rather than the cause. We find that methylation loci are enriched for functional genomic features in multiple tissues (P < 0.05), and show that sentinel methylation markers identify gene expression signatures at 38 loci (P < 9.0 × 10 , range P = 5.5 × 10 to 6.1 × 10 , n = 1,785 samples). The methylation loci identify genes involved in lipid and lipoprotein metabolism, substrate transport and inflammatory pathways. Finally, we show that the disturbances in DNA methylation predict future development of type 2 diabetes (relative risk per 1 standard deviation increase in methylation risk score: 2.3 (2.07-2.56); P = 1.1 × 10 ). Our results provide new insights into the biologic pathways influenced by adiposity, and may enable development of new strategies for prediction and prevention of type 2 diabetes and other adverse clinical consequences of obesity.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.