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LIU, Yan Qing; ZHAO, Li; GAO, Ya Bing; DONG, Ji; WANG, Hui; YAO, Bin Wei; ZHOU, Hong Mei; WANG, Shui Ming; PENG, Rui Yun
Biomedical and environmental sciences, 11/2015, Letnik: 28, Številka: 11Journal Article
To investigate the mechanisms of microwave induced pacemaker cell injuries, Wistar rats and the primary pacemaker cells of newborn Wistar rats were exposed to microwave at average power density of 50 mW/cm2. Slower spontaneous beating rate, intercellular Ca2＋ aggregation and cell membrane perforation were detected immediately after the exposure. Moreover, hyperpolarizationactivated cyclic nucleotide-gated cation channel 4 （HCN4） was down-regulated immediately after the exposure and up-regulated at 12 h after the exposure. In the sinoatrial node （SAN） of the rats,
