E-viri
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Akagi, Keiko; Li, Jingfeng; Broutian, Tatevik R; Padilla-Nash, Hesed; Xiao, Weihong; Jiang, Bo; Rocco, James W; Teknos, Theodoros N; Kumar, Bhavna; Wangsa, Danny; He, Dandan; Ried, Thomas; Symer, David E; Gillison, Maura L
Genome research, 02/2014, Letnik: 24, Številka: 2Journal Article
Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of "looping" by which HPV integrant-mediated DNA replication and recombination may result in viral-host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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