Abstract Objective To analyse the efficiency of the H Pipelle endometrial sampler at “no touch” (vaginoscopic) diagnostic hysteroscopy in terms of biopsy adequacy for histological diagnosis. Study design Retrospective descriptive study of 200 premenopausal women including comparison with previously published data on traditional biopsy instruments. Results Biopsy was adequate in 82% of cases overall, rising to 87% in those without submucous fibroids or polyps. Comparison with published data on other biopsy instruments shows that the H Pipelle is at least as efficient. Conclusion The H Pipelle appears to be at least as effective as traditional endometrial samplers even after hysteroscopy but allows hysteroscopy and biopsy to be done using a purely “no touch” (vaginoscopic) technique.