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Gustavsen, Marte W; Viken, Marte K; Celius, Elisabeth G; Berge, Tone; Mero, Inger-Lise; Berg-Hansen, Pål; Aarseth, Jan H; Myhr, Kjell-Morten; Søndergaard, Helle B; Sellebjerg, Finn; Oturai, Annette B; Hillert, Jan; Alfredsson, Lars; Olsson, Tomas; Kockum, Ingrid; Lie, Benedicte A; Harbo, Hanne F
Journal of neuroimmunology, 09/2014, Letnik: 274, Številka: 1Journal Article
Abstract Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n = 3876). Specific KIR ligands were associated with patients when compared to controls (n = 3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.
