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Kennedy-Smith, Joshua J; Arora, Nidhi; Billedeau, J. Roland; Fretland, Jennifer; Hang, Julie Q; Heilek, Gabrielle M; Harris, Seth F; Hirschfeld, Donald; Javanbakht, Hassan; Li, Yu; Liang, Weiling; Roetz, Ralf; Smith, Mark; Su, Guoping; Suh, Judy M; Villaseñor, Armando G; Wu, Jeffrey; Yasuda, Dennis; Klumpp, Klaus; Sweeney, Zachary K
07/2010, Letnik: 1, Številka: 1Journal Article
New pyridone non-nucleoside reverse transcriptase inhibitors (NNRTIs) were prepared and several flexible routes to this class of inhibitor were identified. These NNRTIs were active inhibitors of the replication of wild-type and NNRTI-resistant HIV. Structure-based drug design was used to optimize the activity of the compounds against NNRTI-resistant mutants. The co-crystal structure of inhibitor 2b in the NNRTI binding pocket of HIV reverse transcriptase (HIVRT) is also described. New pyridone non-nucleoside reverse transcriptase inhibitors (NNRTIs) were prepared, and several flexible routes to this class of inhibitor were identified.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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