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Valot, Gaëlle; Regens, Christopher S.; O'Malley, Daniel P.; Godineau, Edouard; Takikawa, Hiroshi; Fürstner, Alois
Angewandte Chemie (International ed.), September 2, 2013, Letnik: 52, Številka: 36Journal Article
Orchestrated yet nonconsonant: The challenge posed by the “umpoled” 1,4‐dioxygenation pattern characteristic for the polyketide frame of amphidinolide F was mastered by a late‐stage ring‐closing alkyne metathesis followed by a directed transannular hydration under the aegis of a carbophilic π‐acid catalyst. This concordant strategy enabled a concise total synthesis of this enticing marine natural product.
