ABSTRACT PSR B1259-63 is a gamma-ray binary system with a radio pulsar orbiting an O9.5Ve star, LS 2883, with a period of ${\sim} 3.4$ yr. Close to the periastron the system is detected at all wavelengths, from radio to the TeV energies. The emission in this time period is believed to originate from the interaction of LS 2883 and pulsar’s outflows. The observations of four periastra passages taken in 2010–2021 show strong correlation of the radio and X-ray light curves with two peaks just before and after the periastron. The observations of the latest 2021 periastron passage reveal the presence of the 3rd X-ray peak and subsequent disappearance of radio/X-ray flux correlation. In this paper, we present the results of our optical, radio, and X-ray observational campaigns on PSR B1259-63 performed in 2021 accompanied with the analysis of the publicly available GeV Fermi/LAT data. We compare the properties of different periastron passages, discuss the obtained results and show that they can be explained in terms of the 2-zone emission model proposed by us previously.