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Makshakova, O.N.; Bogdanova, L.R.; Faizullin, D.A.; Ermakova, E.A.; Zuev, Yu. F.; Sedov, I.A.
Carbohydrate polymers, 01/2021, Letnik: 252Journal Article
•k-Carrageenan retains its overall secondary structure upon complexation with lysozyme.•Unordered k-carrageenan perturbs lysozyme loops and stabilizes β-structure.•Helical k-carrageenan does not remarkably affect lysozyme structure. The interactions between κ-carrageenan and hen egg-white lysozyme have been studied. In dilute solutions, the insoluble complexes with constant κ-carrageenan/lysozyme ratio of 0.3, or 12 disaccharide units per mole of protein are formed. FTIR-spectroscopy revealed that κ-carrageenan retains its unordered conformation and induces the rise of β-structure in lysozyme. In the complexes formed in concentrated mixtures, κ-carrageenan adopts helical conformation and lysozyme retains its native-like structure. These complexes contain 21 disaccharide units per mole of protein. Molecular modeling showed that flexible coil and rigid double helix of κ-carrageenan have different binding patterns to lysozyme surface. The latter has a strong preference to positively charged spots in lysozyme α-domain while the former also interacts to protein β-domain and stabilizes short-living β-structures. The obtained results confirm the preference of unordered κ-carrageenan to β-structure rich protein regions, which can be further used in the development of carrageenan-based protection of amyloid-like aggregation of proteins.
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