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Liu, Lijun; Marwitz, Adam J.V; Matthews, Brian W; Liu, Shih-Yuan
Angewandte Chemie (International ed.), 01/2009, Letnik: 48, Številka: 37Journal Article
Enzymes BN tricked: High‐resolution protein crystallography indicates that unnatural 1,2‐dihydro‐1,2‐azaborines bind inside the nonpolar cavity of T4 lysozyme L99A (see picture) in a fashion that is very similar to the binding of their “natural” all‐carbon isosteres. These studies show that 1,2‐azaborines can serve as boron‐containing, hydrophobic arene mimics in biomedical research.
