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Mocharla, Vani P.; Colasson, Benoit; Lee, Lac V.; Röper, Stefanie; Sharpless, K. Barry; Wong, Chi-Huey; Kolb, Hartmuth C.
Angewandte Chemie (International ed.), December 17, 2004, Letnik: 44, Številka: 1Journal Article
Target‐guided synthesis: Rather than making and screening thousands of compounds for lead discovery, in situ click chemistry employs the biological target itself to assemble its inhibitors by selectively binding and interconnecting reagents within the confines of its binding sites. Subnanomolar inhibitors of carbonic anhydrase II were produced by the enzyme from simple azide and acetylene precursors (see picture).
