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KRSTIC, Natalija M; BJELAKOVIC, Mira S; ZIZZAK, Zeljko; PAVLOVIC, Mirjana D; JURANIC, Zorica D; PAVLOVIC, Vladimir D
Steroids, 05/2007, Letnik: 72, Številka: 5Journal Article
The antiproliferative activity of previously synthesized ( Z)-cholest-4-en-6-one oxime ( 1), ( E)-cholest-4-en-6-one oxime ( 2), 7-aza-B-homocholest-4-en-6-one ( 3) and 6-aza-B-homocholest-4-en-7-one ( 4) and newly synthesized 6-thioxo-7-aza-B-homocholest-4-ene ( 5) and 6-aza-7-thioxo-B-homocholest-4-ene ( 6) was tested for their possible effects against two human tumor cell lines, cervical carcinoma (HeLa) and chronic myelogenous leukemia (K-562). Compounds 1– 6, exerted a dose-dependent antiproliferative effect toward cell lines used in experimental design, showing high selectivity in their action for tumor cells in comparison to normal immunocompetent cells (non-stimulated PBMC and PHA-stimulated PBMC). Compounds 2, 3 and 4 exhibited a very high but selective antitumor activity, by inducing apoptosis in sensitive, for that purpose targeted tumor cell line (HeLa cells). Low toxic effect upon both non-stimulated, and PHA stimulated PBMCs from control, healthy volunteers, has been detected for compounds 1, 2, 3 and 4. The possible reasons for profound differences in the effects of this spectrum of steroidal compounds between tumor cell lines and normal stimulated and non-stimulated PBMCs are discussed. The molecular mechanisms for apoptotic events in HeLa cell line are suggested. The guidelines for further research are underlined.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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