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  • Bioprinting of Thermorespon...
    Suntornnond, Ratima; An, Jia; Chua, Chee Kai

    Macromolecular materials and engineering, January 2017, Letnik: 302, Številka: 1
    Journal Article

    Bioprinting is a breakthrough technology that integrates living cells, biomaterials, and a robotic dispensing system to create complex structures that mimic original tissues and organs. One of the main components of bioprinting is bioink and hydrogel is essential in bioink formulation. In bioprinting, hydrogel should have good biocompatibility, provide good resolution, and have sufficient mechanical strength to support printed structures. Recently, thermoresponsive hydrogels have gained more and more attention due to their unique characteristic of tunable sol‐gel (liquid to solid phase) transition when temperature is changed, and many biomedical applications from drug delivery devices to tissue scaffolds have demonstrated the potentials of bioprinted thermosresponsive constructs. In this review, we discuss bioprintable thermoresponsive hydrogels with a particular focus on their gelation mechanisms, fabrication strategies using bioprinter and applications. The future prospects of the bioprinting‐based use of thermoresponsive hydrogels for next generation tissue engineering have also been discussed. Thermoresponsive hydrogels have recently gained more and more attention to bioprinting community due to their unique characteristic of tunable sol‐gel (liquid to solid phase) transition when temperature is changed. In this review, properties, bioprinting techniques, applications, and future aspects of bioprintable thermoresponsive hydrogels are critically discussed.