E-viri
Recenzirano
-
Zupanc, Tomaž; Pregelj, Peter; Tomori, Martina; Komel, Radovan; Paska, Alja Videtič
Neuroscience letters, 02/2011, Letnik: 490, Številka: 1Journal Article
▶ Association between suicide and alcohol-related suicide for SNP Rs1843809 in TPH2. ▶ Tendency for association for SNP Rs1386493 and alcohol-related suicide in TPH2. ▶ More impulsive, verbal aggressive behavior in suicide victims with alcohol misuse. Substantial evidence from family, twin, and adoption studies corroborates implication of genetic and environmental factors, as well as their interactions, on suicidal behavior and alcoholism risk. Serotonergic disfunction seems to be involved in the pathophysiology of substance abuse, and has also an important role in suicidal behavior. Recent studies of the tryptophan hydroxylase 2 showed mild or no association with suicide and alcohol-related suicide. We performed SNP and alcohol analysis on 388 suicide victims and 227 controls. The results showed association between suicide ( P( χ 2) = 0.043) and alcohol-related suicide ( P( χ 2) = 0.021) for SNP Rs1843809. A tendency for association was determined also for polymorphism Rs1386493 ( P( χ 2) = 0.055) and alcohol-related suicide. Data acquired from psychological autopsies in a subsample of suicide victims ( n = 79) determined more impulsive behavior ( P( χ 2) = 0.016) and verbal aggressive behavior ( P( χ 2) = 0.025) in the subgroup with alcohol misuse or dependency. In conclusion, our results suggest implication of polymorphisms in suicide and alcohol-related suicide, but further studies are needed to clarify the interplay among serotonergic system disfunction, suicide, alcohol dependence, impulsivity and the role of TPH2 enzyme.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.