Quasi-static and dynamic compressive tests with a series loading rates were conducted on (Zr0.6336Cu0.1452Ni0.1012Al0.12)97Tm3 bulk amorphous alloy at cryogenic temperature. It is found that mechanical properties of the alloy such as yield strength and plasticity are obviously dependent on temperature and strain rate. The plastic strain of the specimens at 298 K and 77 K is 8.4% and 13.7% respectively under quasi-static load with strain rate of 1 × 10−4 s−1. Additionally, the dynamic mechanical properties of amorphous alloys at different strain rates were tested by split Hopkinson pressure bar(SHPB) to unveil the dynamic deformation behaviors at cryogenic temperature of 177 K and 77 K. Compared with the results of quasi-static compression, strain rate softening phenomenon can be observed under dynamic loading, but the compressive strength of specimens increases significantly with the decrease of temperature. Moreover, the specimens have no obvious plastic deformation under dynamic loading. Compared with room temperature, the improvement of quasi-static and dynamic compressive strength of the alloy at cryogenic temperature can be attributed to the strong interatomic binding force between the alloy elements. •Quasi-static and dynamic deformation behavior of a Zr-based amorphous alloys at cryogenic temperature was compared.•Relationships between fracture mechanism and temperature under different stress states were discussed.•The effect of stress state on the dynamic fracture behavior of Zr-based metallic glass was analyzed.