In recent decades, information and communication technology (ICT) has revolutionized the world affecting every aspect of life, including education, business, social activities, and environment. Consequently, the studies linking ICT and environmental sustainability are growing owing to its positive and adverse effects on environmental sustainability, and the noticeable disagreement in literature. Therefore, current work examines the criticality of ICT, human capital (education and return on education), and globalization in environmental sustainability, controlling urbanization and economic growth in the Latin American and Caribbean (LCA) region, where economic growth and globalization have substantially increased over the past three decades. Reliable panel econometric techniques, including second-generation unit root tests, Westerlund (2007, 2008) cointegration tests, and continuously-updated fully modified (CUP-BC) and continuously-updated bias-corrected (CUP-FM) long-run estimators are employed on the data for the period 1995–2017. The empirical estimations unfold that ICT (computed by a four components ICT index) and globalization contribute to reduce CO2 emissions. On the dark side, economic growth and urbanization degrade environment. Surprisingly, human capital adds to environmental degradation. The panel causality results reveal that ICT and globalization Granger cause CO2 emissions. These unique findings provide new insight to alleviate environmental degradation in the LCA region. Based on these outcomes, a comprehensive set of policies are directed for environmental sustainability. Display omitted