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Lalancette, Eve; Charlebois-Poirier, Audrey-Rose; Agbogba, Kristian; Knoth, Inga Sophia; Côté, Valérie; Perreault, Sébastien; Lippé, Sarah
Brain research, 11/2023, Letnik: 1818Journal Article
Display omitted •Preserved suppression of oscillatory activity in response to repeated vowels in school-aged children with NF1.•Children with NF1 show increased spectral power, mainly in the theta frequency band, in the change detection response.•Higher alpha spectral power in response to change was associated with fewer ADHD-related symptoms. Children with neurofibromatosis type 1 (NF1) are at increased risk of developing cognitive problems, including attention deficits and learning difficulties. Alterations in brain response to repetition and change have been evidenced in other genetic conditions associated with cognitive dysfunctions. Whether the integrity of these fundamental neural responses is compromised in school-aged children with NF1 is still unknown. In this study, we examined the repetition suppression (RS) and change detection responses in children with NF1 (n = 36) and neurotypical controls (n = 41) aged from 4 to 13 years old, using a simple sequence of vowels. We performed time–frequency analyses to compare spectral power and phase synchronization between groups, in the theta, alpha and beta frequency bands. Correlational analyses were performed between the neural responses and the level of intellectual functioning, as well as with behavioral symptoms of comorbid neurodevelopmental disorders measured through parental questionnaires. Children with NF1 showed preserved RS, but increased spectral power in the change detection response. Correlational analyses performed with measures of change detection revealed a negative association between the alpha-band spectral power and symptoms of inattention and hyperactivity. These findings suggest atypical neural response to change in children with NF1. Further studies should be conducted to clarify the interaction with comorbid neurodevelopmental disorders and the possible role of altered inhibitory mechanisms in this enhanced neural response.
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