Background: The aim of this study is to examine the relationship between mental endurance and psychological well-being of male chess players. Methods: 87 male active licensed chess players participated in the study. Ethics committee approval was obtained for the research. Mental endurance scale, psychological well-being scale and personal information form were used to collect the research data. Confirmatory factor analysis (CFA) was performed for the research scales. In addition to descriptive statistics, correlation and regression analyzes are included in the relational model. Results: Considering the average values obtained from the research scales, it was found that the mental endurance and psychological well-being levels of chess players were high, and there was a positive and high level relationship between mental endurance and psychological well-being within the scope of the relational model (r = 0.742; p < 0.001), and it has been found that mental endurance has a significantly high and positive contribution on psychological well-being in sports (β= 0.745; p < 0.001). Conclusions: It can be said that as the mental endurance of chess players improves, their psychological health will also be positively affected. It can also be stated that, especially by directing the young generation to chess, their mental endurance and psychological health will be improved in a positive way.