Axially chiral indole‐based frameworks have been recognized as a class of important five‐membered heterobiaryls and developing catalytic asymmetric approaches for constructing these frameworks in an enantioselective manner is highly desirable. In recent years, synthetic chemists have paid much attention to this research field, and rapid developments have occurred. At this point, a range of axially chiral indole‐based scaffolds have been constructed via various catalytic asymmetric reactions based on different strategies. Thus, the catalytic asymmetric construction of axially chiral indole‐based frameworks has become an emerging area. This minireview summarizes the rapid advances in this field and gives some insights into future developments, which will help this research field to thrive. Axially chiral indole‐based frameworks have been recognized as an important class of five‐membered heterobiaryls, and the catalytic asymmetric construction of this class of frameworks has become an emerging area. To give an in‐depth understanding of this area, this Minireview not only analyses its history and development trends, but also gives some insights into future developments based on the summarization of the rapid advances in this field.