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  • Etiopathogenesis and risk f...
    Ali, Humaira; Chandraharan, Edwin

    Best practice & research. Clinical obstetrics & gynaecology, April 2021, 2021-Apr, 2021-04-00, 20210401, Letnik: 72
    Journal Article

    Placenta accreta spectrum (PAS) disorders, comprising placenta accreta, increta, and percreta, are associated with serious maternal morbidity and mortality in both the developed and the developing world. The incidence of PAS has increased in the recent years, and the rising rates of cesarean section rate, placenta accreta in previous pregnancies, and other uterine surgeries including myomectomies and repeated endometrial curettage are implicated in its etiopathogenesis. The absolute risk of PAS increases with the number of previous cesarean sections. The PAS remains undiagnosed in one-half to two-thirds of cases, thus increasing maternal morbidity and mortality. Understanding etiopathogenesis and risk factors of this condition allows early diagnosis and planning of delivery, and thereby would help improve maternal and fetal outcomes. •Iatrogenic damage to decidua basalis results in trophoblastic invasion into the myometrium resulting in PAS.•Increasing cesarean section and uterine surgery rates are implicated in the etiopathogenesis of PAS.•Pros and cons of performing elective uterine procedures should take into account its effects on future pregnancy.