E-viri
Recenzirano
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Daum, Sebastian; Erdmann, Frank; Fischer, Gunter; Féaux de Lacroix, Boris; Hessamian-Alinejad, Anahita; Houben, Sabine; Frank, Walter; Braun, Manfred
Angewandte Chemie (International ed.), November 13, 2006, Letnik: 45, Številka: 44Journal Article
A good imitation: Aryl‐1‐indanyl ketones are found to be highly efficient, reversible, cell‐penetrating inhibitors of the human peptidyl prolyl cis/trans isomerase Pin1. Owing to their structure 1, they are assumed to mimic the transition state 2 of the enzymatically catalyzed rotation about the imidic peptide bond preceding a proline residue.
