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Chen, Ting-Hsuan; Liu, Ying-Yu; Jan, Jia-Tsrong; Huang, Ming-Hsi; Spearman, Maureen; Butler, Michael; Wu, Suh-Chin
Antiviral research, October 2017, 2017-Oct, 2017-10-00, 20171001, Letnik: 146Journal Article
Humans infected with H7N9 avian influenza viruses can result in severe pneumonia and acute respiratory syndrome with an approximately 40% mortality rate, and there is an urgent need to develop an effective vaccine to reduce its pandemic potential. In this study, we used a novel PELC/CpG adjuvant for recombinant H7HA (rH7HA) subunit vaccine development. After immunizing BALB/c mice intramuscularly, rH7HA proteins formulated in this adjuvant instead of an alum adjuvant elicited higher IgG, hemagglutination-inhibition, and virus neutralizing antibodies in sera; induced higher numbers of H7HA-specific IFN-γ-secreting T cells and antibody secreting cells in spleen; and provided improved protection against live virus challenges. Our results indicate that rH7HA proteins formulated in PELC/CpG adjuvant can induce potent anti-H7N9 immunity that may provide useful information for H7N9 subunit vaccine development. •PELC/CpG adjuvant as compared to alum elicited higher HI and NT titers in sera.•PELC/CpG adjuvant as compared to alum induced higher numbers of Th1 and ASC in spleen.•PELC/CpG provided improved protection against live virus challenges.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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