A 79-year-old male was diagnosed with a total knee prosthetic infection. He had a history of an episode of Clostridioides difficile-associated diarrhoea a year ago. Clostridioides difficile was isolated from the joint fluid and intraoperative tissue samples, and ribotyping demonstrated that the strain was the same that had caused the diarrheic episode, an infrequent ribotype (RT534). The genetic relatedness suggests that the initial infection occurred during that hospitalization, resulting in a chronic prosthetic infection. We have carried out an extensive literature review of all the cases reported in scientific databases of Clostridioides difficile infections with extraintestinal presentation and their relationship with previous colitis. Display omitted •Difficile causes indolent infections that can take a long time to become apparent.•Extraintestinal C. difficile infection is usually preceded by an intestinal disease.•Suspect a C. difficile joint prosthetic infection in a patient with previous diarrhoea.•There is a lack of consensus for the treatment of extraintestinal C. difficile infection.